Introduction: Immunological studies in oncology often reveals different immune disorders, especially after radiotherapy, chemo-therapy, surgical operations, which creat conditions for persistent immunodeficiency and recurrent tumor. For correction of immune system the Biochronotherapy Center applied the method of Selective Chronophototherapy (SCPT) with chlorin E6, including laser therapy. The radiation source is laser with wavelength of 662 nm, 2 W with biofeedback sensors of respiration and pulse. The expediency of SCPT method for immunocorrection was indicated by immunological study of cancer patients. Materials and Methods: The study involved 45 patients with breast cancer (ВС) and 25 patients with skin melanoma (SM) before and during 4-month treatment by SCPT with 1-month intervals. Immunological investigations included: leukocyte, lymphocyte count; immunophenotyping on 10 indicators; determination of phagocytic activity, spontaneous oxygen metabolism of neutrophils and concentration of serum IgA, IgG, IgM. Processing of results was made by FoxPro.

Results: Initially, all patients had pathological changes in the immune system related primarily cell-mediated immunity. In pa-tients with ВС was observed deficiency of cytotoxic T-lymphocytes (CD8) and CD56NK-cells, with MS— the suppression of T-helper- level (CD4) and CD16NK-cells. After 1 month SCPT application in 96% of patients was observed positive changes in immunological parameters. Primarily, at ВС normalized CD8 and CD56NK, and in case of SM- CD4 and CD16NK. The low level of CD54 and CD95 expression increased to the physiological norm both at ВС and SM in 95% and 87% of patients respectively. This correlated with decrease in malignant inflammatory focus. Initially high expression of CD71 after 1 month normalized in 50% of patients both with ВС and SM. Others had a significant trend towards reduction. Whereby was noted the decrease or (in some cases) complete absence of metastasis. Subsequent immunological investigations within 4 months observed stabilization of reduced immunological parameters that affect the clinical status of patients: improved appetite, efficiency, overall tonus, patients reported improved quality of life.

Conclusion: Thus, the application of SCPT method contributes to the normalization and stabilization of reconstructed immunologic parameters, mainly cellular immunity. Achieved level of immune persists for a long time. Currently the clinical and immunological status of patients with ВС and SM and with other malignant pathologies is observed.

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